Our mini-review entitled « In vitro models to study viral-induced asthma exacerbation: a short review for a key issue » has been published in Frontiers In Allergy !

Asthma is a major health problem worldwide, which can be associated with morbidity and mortality. Respiratory viral infections are one of the most important causes of asthma exacerbation, but the underlying virus-induced mechanisms are incompletely described.

To meet this urgent need and develop new efficient therapies, it is necessary to exploit relevant in vitro models in order to study the mechanisms leading to the various aspects of the pathophysiology associated to virus-induced asthma exacerbation.

Our review summarizes current in vitro systems, ranging from classical cell cultures to 3D airway epithelium models, including organoids, and discuss their advantages and limitations to decipher different aspects of virus-related asthma pathophysiology and exacerbation.

Read the publication : https://lnkd.in/eMhWJNqn