This study aimed to characterize the infection kinetics and long-term epithelial innate responses to IAV H1N1, RSV-A, and SARS-CoV-2 in a human nasal epithelial model (MucilAir™) cultured at air-liquid interface. Replication, tissue integrity, host gene expression, and epithelium morphology were assessed up to 28 days post-infection (dpi). Our results show that IAV, RSV, and SARS-CoV-2 trigger distinct, long-lasting epithelial responses in the absence of immune cells, highlighting virus-specific impacts on airway tissue structure and function. Bernadett Boda (PhD) and Rose-Marie Bonfante from Epithelix will present our poster titled “Respiratory virus-specific long-lasting footprint of infection in human nasal airway epithelium model”.